货号：ABE124

品牌：Merck Millipore

规格：

目录价：￥4113.00

市场价格：￥3496.05

会员价格：￥3290.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PRMT6 Antibody | Cat. No. ABE124 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~45 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~41 kDa, and ~32 kDa. View All» Immunogen: GST-tagged recombinant protein corresponding to human PRMT6. View All» Background Information: Protein argentine methyltransferase 6 (PRMT6) is a known coregulator of gene expression. It acts as a repressor as well as an activator by asymmetric dimethylation of Histone H3 at R2 (H3 R2me2a). It is also known to methylate Histone H3 at Lys-4 (H3K4me2 and H3K4me3), Histone H2A at Arg-3 (H2AR3me) and Histone H4 at Arg-3 (H4R3me). PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Studies show that PRMT6 catalyzes the formation of asymmetrical dimethylarginine (aDMA) and omega-N monomethylarginine (MMA), but demonstrates greater affinity for aDMA formation. PRMT6 regulates other targets such as, but not limited to, HOXA2 the p53 tumor suppressor, and thrombospondin-1. PRMT6 is suggested to play a role in innate immunity against HIV-1 through its interactions with Rev, Tat and Nucleocapsid protein p7. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: Human testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human testis tissue lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected PRMT6 in 10 µg of human testis tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96LA8 View All» Entrez Gene Number: NP_060607 View All» Gene Symbol:

• PRMT6

• HRMT1L6
  View All» Alternate Names:
  • Protein arginine N-methyltransferase 6

  • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6

  • Histone-arginine N-methyltransferase PRMT6
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-PRMT6 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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