货号：ABE115

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRF-2 Antibody | ABE115 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 40 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human IRF-2. View All» Isotype: IgG View All» Background Information: Interferon regulatory factor 2(IRF-2) is a nuclear transcriptional repressor containing a single tryptophan pented repeat DNA-binding domain. This protein is a member of the IRF family, a group of proteins known to interact with various DNA-binding site sequences to regulate target gene transcription. IRF-2 represses type I IFN and IFN-inducible MHC class I genes (ICS) by binding to their upstream, regulatory regions. It is also an activator for a variety of other genes. These genes include IL7, which IRF2 activates by binding to the ISRE promoter region, and H4, activated by and serving as a regulatory pathway for IRF-2 in the cell cycle. Studies have also shown IRF-2 to block IRF-1 transcriptional activation, and that it may also function as a tumor suppressor. Expression is observed in the epithelium of the colon and has also been observed in lamina propria. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected IRF-2 in NIH/3T3 and A431 cells. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 0.2 µg/mL of this antibody detected IRF-2 on 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in PBS containing 0.5% Azide, 0.02% BSA and 0.002% Thimerosal. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P14316 View All» Entrez Gene Number: NP_002190 View All» Gene Symbol:
  • IRF-2

  • IRF-2
    View All» Alternate Names: interferon regulatory factor 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. SUBUNIT STRUCTURE: Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed throughout the epithelium of the colon. Also expressed in lamina propria. INDUCTION: By viruses and IFN.PTM: Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.SEQUENCE SIMILARITIES: Belongs to the IRF family.Contains 1 tryptophan pentad repeat DNA-binding domain. View All» Product Name: Anti-IRF-2 View All» Concentration: 0.2 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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