货号：ABD48

品牌：Merck Millipore

规格：

目录价：￥4025.00

市场价格：￥3421.25

会员价格：￥3220.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-STMN2 Antibody | ABD48 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes STMN2 at the regulatory/phosphorylation domain. View All» Molecular Weight: ~21 kDa observed View All» Epitope: Regulatory/phosphorylation domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the regulatory/phosphorylation domain of human STMN2. View All» Background Information: Stathmin-like 2 (STMN2) protein is a phospho-protein and functions in microtubule dynamics and signal transduction. Studies show STMN2 plays a regulatory role in neuronal growth and thought to be involved in osteogenesis. Reduced levels, i.e. reduction in expression, have been associated with Down's syndrome and Alzheimer's disease. Data also suggests that STMN2 may play a role in modulating membrane interaction with the cytoskeleton during neurite outgrowth. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Rat based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:200 dilution from a representative lot detected STMN2 in normal rat brain tissue. View All» Control: Mouse fetal brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse fetal brain tissue lysate.Western Blot Analysis: 0.2 µg/mL of this antibody detected STMN2 on 10 µg of mouse fetal brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q93045 View All» Entrez Gene Number: NP_008960 View All» Gene Symbol:
  • STMN2

  • SCG10

  • SCGN10
    View All» Alternate Names:
    • Stathmin-2

    • Superior cervical ganglion-10 protein

    • Protein SCG10
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]. View All» UniProt Summary: FUNCTION: Is a key regulator of neurite extension through regulation of microtubule instabilily (By similarity).SUBUNIT STRUCTURE: Interacts with ITM2C. SUBCELLULAR LOCATION: Cytoplasm By similarity. Cytoplasm › perinuclear region (By similarity). Cell projection › growth cone (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic side Potential. Cell projection › axon (By similarity). Note: Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms (By similarity).TISSUE SPECIFICITY: Neuron specific.PTM: Sumoylated. SEQUENCE SIMILARITIES: Belongs to the stathmin family. View All» Product Name: Anti-STMN2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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