货号：ABD15

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Goosecoid (GSC) Antibody | ABD15 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Goosecoid near the C-terminus. View All» Molecular Weight: ~28 kDa observed View All» Epitope: Near C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human Goosecoid near the C-terminus. View All» Background Information: Homeobox protein goosecoid (GSC) has been shown to affect neuronal differentiation by slowing down the cell cycle and by up-regulating neurite outgrowth. GSC is thought to be important in the Spemann’s organizer by repressing Xwnt8 and promoting head organizer action. High levels of GSC have been found in human tumors and research has shown that GSC does advance tumor cell malignancy. Recently, a Wwp2-GSC pathway has been identified that may be useful in discouraging craniofacial abnormalities. View All» Species Reactivity:

• Human

• Pig

• Rat

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with pig, rat, chimpanzee, and rhesus monkey based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:1,000 dilution from a previous lot detected Goosecoid in normal human colon and human colon cancer tissues. View All» Control: Human colon tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human colon tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Goosecoid on 10 µg of human colon tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P56915 View All» Entrez Gene Number: NP_776248 View All» Gene Symbol: GSC View All» Alternate Names:
  • goosecoid homeobox

  • homeobox protein goosecoid
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Belongs to the paired homeobox family. Bicoid subfamily.Contains 1 homeobox DNA-binding domain. View All» Product Name: Anti-Goosecoid (GSC) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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