货号：ABC14

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ATG5 Antibody | ABC14 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~55 kDa observed. The observed band at ~55 kDa represents the ATG12-ATG5 conjugated form in endogenous lysates (Huang, J., et al. (2009) PNAS. 106(15):6226-6231). May detect full length 32 kDa and cleaved 22 kDa forms at higher concentrations. View All» Immunogen: KLH-conjugated linear peptide corresponding to human ATG5. View All» Background Information: ATG5 (also known as autophagy protein 5 or APG5L) conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. ATG5-conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process, where its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. View All» Species Reactivity:

• Human

• Mouse

• Rabbit

• Bovine

• Pig

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rabbit. Predicted to react with Bovine, Porcine, and Chimpanzee based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:600 dilution from a representative lot detected ATG5 in ductal breast carcinoma in situ tissue. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected ATG5 in 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9H1Y0 View All» Entrez Gene Number: NP_004840 View All» Gene Symbol:
  • APG5

  • APG5-LIKE

  • APG5L

  • ASP

  • hAPG5
    View All» Alternate Names:
    • APG5 autophagy 5-like

    • APG5 autophagy 5-like (S. cerevisiae)

    • APG5 (autophagy 5, S. cerevisiae)-like

    • ATG5 autophagy related 5 homolog (S. cerevisiae)

    • ATG5 autophagy related 5-like

    • Apoptosis-specific protein

    • apoptosis specific protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity).May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. SUBCELLULAR LOCATION: Cytoplasm. Note= Colocalizes with nonmuscle actin.TISSUE SPECIFICTY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.INDUCTION: By apoptotic stimuli.PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.SEQUENCE SIMILARITIES: Belongs to the ATG5 family. View All» Product Name: Anti-ATG5 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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