货号：ABC112

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-ULK1/ATG1 (Ser758) Antibody | ABC112 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the ULK1/ATG1 phosphorylated at Ser758. View All» Molecular Weight: ~120 kDa observed View All» Epitope: Phosphorylated Ser758 View All» Immunogen: KLH-conjugated linear peptide corresponding to human ULK1/ATG1 phosphorylated at Ser758. View All» Background Information: ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. ULK1 may play an important role in neuronal development: Elimination of ULK1's enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse, Rat, and Bovine based on 100% sequence homology. View All» Application Notes: Peptide Inhibition Analysis: A 1:1,000 dilution from a representative lot blocked phospho-ULK1/ATG1 (Ser758) in serum-starved A431 cell lysates. View All» Control: A431 and serum starved A431 cell lysates. View All» Quality Assurance: Evaluated by Western Blot in A431 and serum starved A431 cell lysates.Western Blot Analysis: A 1:1,000 dilution of this antibody detected ULK1/ATG1 on 10 µg of A431 and serum starved A431 cell lysates.. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75385 View All» Entrez Gene Number: NP_003556 View All» Gene Symbol: ULK1 View All» Alternate Names:

• Serine/threonine-protein kinase ULK1

• Autophagy-related protein 1 homolog

• ATG1

• hATG1

• Unc-51-like kinase 1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Peptide Inhibition Assay
    View All» Product Name: Anti-phospho-ULK1/ATG1 (Ser758) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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