货号：ABC11

品牌：Merck Millipore

规格：200Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bax (N-terminus) Antibody | ABC11 View All» Replaces: 06-499 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes BAX. View All» Molecular Weight: ~ 21 kDa View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human BAX at and around the N-terminus. View All» Background Information: BAX (BCL2-associated X protein) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. View All» Species Reactivity:

• Human

• Bovine

• Feline

• Chimpanzee

• Canine
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with bovine, feline, rhesus monkey, chimpanzee, and canine based on 100% sequence homology. Rat (90%), Mouse (86%). View All» Application Notes: Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated BAX from 500 µg of HL60 cell lysate.Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected BAX in colorectal and ductal carcinoma tissue.Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected BAX in MCF7 cells. View All» Control: HL60 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HL60 cell lysate.Western Blot Analysis: 0.125 µg/ml of this antibody detected BAX on 10 µg of HL60 cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q07815 View All» Entrez Gene Number: NP_620119 View All» Gene Symbol:
  • BAX

  • BCL2L4

  • Bcl2-L-4
    View All» Alternate Names:
    • BCL2-associated X protein

    • Bcl-2-like protein 4

    • apoptosis regulator BAX
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein.| Q07812 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis.SIZE: 41 amino acids; 4678 Da SUBUNIT: Interacts with HN.SUBCELLULAR LOCATION: Cytoplasm.DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family DISEASE: Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.SIMILARITY: Belongs to the Bcl-2 family. | Q07814 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.# Belongs to the Bcl-2 family. | P55269 ## Belongs to the Bcl-2 family. | Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity).# Belongs to the Bcl-2 family. View All» Product Name: Anti-Bax (N-terminus) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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