货号：AB9882

品牌：Merck Millipore

规格：100UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Huntingtin-Interacting Protein 1 Related (HIP1R) Antibody | AB9882 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Huntingtin-interacting protein 1 related (HIP1R). By Western blot the antibody recognizes a band at ~116 kDa on P2 microsomal fraction from embryonic rat brain. View All» Molecular Weight: ~116 kDa View All» Immunogen: Synthetic peptide View All» Background Information: Huntingtin-Interacting protein-1 related (HIP1R) is an actin-binding protein that is considered an element of the clathrin-coated pits and vesicles and polymerizes actin. HIP1R is essential for normal actin organization and endocytosis. HIP1R is equipped with a epsin N-terminal homology domain which allows it to bind 3-phosphorylated inositol lipids, which allows HIP1R to function as a tyrosine kinase stabilizing receptor and plays a role in overall cell growth and survival. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Application Notes: Western Blot: a 1:500-1:2,000 dilution of this antibody detected Huntingtin-interacting protein 1 related (HIP1R) in 10 µg of rat brain extract and mouse brain post-nuclear supernatant.A 1:500-1:2,000 dilution of this antibody detected Huntingtin-interacting protein 1 related (HIP1R) in 10 µg of rat brain extract and mouse brain post-nuclear supernatant.Immunocytochemistry: a previous lot of this antibody was used by an independent laboratory for IC of human cells. (Poupon, V., et al. (2008). PNAS. 105(1): 168-173.)Optimal working dilutions must be determined by end user. View All» Presentation: Liquid View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O75146 View All» Entrez Gene Number: NM_003959.1 View All» Gene Symbol:
  • HIP1R

  • FLJ14000

  • HIP3

  • ILWEQ

  • HIP12

  • Hip1-related

  • MGC47513

  • KIAA0655
    View All» Alternate Names: HIP1R View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: O75146 # Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton.SIZE: 1068 amino acids; 119388 Da SUBUNIT: Interacts with actin and huntingtin interacting protein 1 (HIP1). Does not interact with huntingtin (By similarity).SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By similarity). Intracytoplasmic membrane (By similarity). Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region (By similarity).TISSUE SPECIFICITY: Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.DOMAIN: SwissProt: O75146 The talin-like domain binds F-actin (By similarity).SIMILARITY: Belongs to the SLA2 family. & Contains 1 ENTH (epsin N-terminal homology) domain. & Contains 1 I/LWEQ domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Huntingtin-Interacting Protein 1 Related (HIP1R) Antibody | AB9882 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Purified View All» Host: Rabbit View All»
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