货号：AB9880

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Huntingtin-Interacting Protein (HIP1) Antibody | AB9880 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Huntingtin-interacting protein 1 (HIP1). By Western blot the antibody recognizes a band at ~116 kDa on P2 microsomal fraction from embryonic rat brain. View All» Molecular Weight: 116 kDa View All» Immunogen: Synthetic peptide View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Western blot: 1:500-1:1,000 on P2 microsomal fraction from embryonic rat brain.Optimal working dilutions must be determined by end user. View All» Presentation: Liquid View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O00291 View All» Entrez Gene Number: NM_005338.4 View All» Gene Symbol:
  • HIP1

  • HIP-I

  • MGC126506

  • ILWEQ
    View All» Alternate Names: HIP1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: O00291 # May play a functional role in the cell filament networks.SIZE: 1030 amino acids; 115442 Da SUBUNIT: Binds huntingtin. This interaction is restricted to the brain. Binds to Hippi.SUBCELLULAR LOCATION: Intracytoplasmic membrane.TISSUE SPECIFICITY: Ubiquitously expressed with the highest level in brain.SIMILARITY: SwissProt: O00291 ## Belongs to the SLA2 family. & Contains 1 ENTH (epsin N-terminal homology) domain. & Contains 1 I/LWEQ domain.MISCELLANEOUS: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease. View All» Brand Family: Chemicon View All» Product Name: Anti-Huntingtin-Interacting Protein (HIP1) Antibody | AB9880 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Purified View All» Host: Rabbit View All»
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