货号：AB9842

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Munc-18 (Ser515) Antibody | AB9842 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Munc-18, phospho Serine 515. The antibody recognizes a protein of ~65 kDa corresponding to Munc-18, phospho Serine 515 in lysates from rat cortex. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide. View All» Immunogen: Synthetic peptide of amino acids surrounding the phosphoSerine 515 site of rat Munc-18. View All» Modifications: Phosphorylation View All» Species Reactivity: Rat View All» Species Reactivity Note: The immunogen has 100% homology with human, mouse, non-human primates, bovine, canine, chicken and Xenopus. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/mL BSA and 50% glycerol. View All» Storage Conditions: Maintain at -20degC in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. View All» UniProt Number: P43121 View All» Entrez Gene Number: NM_006500.2 View All» Gene Symbol:

• MCAM

• Gicerin

• MUC18

• CD146
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P43121 # Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.SIZE: 646 amino acids; 71607 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.SIMILARITY: SwissProt: P43121 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 Ig-like V-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-phospho-Munc-18 (Ser515) Antibody | AB9842 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Presynaptic View All» Format: Affinity Purified View All» Host: Rabbit View All»
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