货号：AB9568

品牌：Merck Millipore

规格：50UL

目录价：￥4131.00

市场价格：￥3511.35

会员价格：￥3304.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurofilament L Antibody | AB9568 View All» Replaces: AB1983 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Neurofilament-Light (NF-L) View All» Molecular Weight: 68-70 kDa View All» Immunogen: Purified porcine NF-L View All» Background Information: Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10 nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexes of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Feline

• Canine

• Pig

• Bovine
  View All» Species Reactivity Note: Human, rat, mouse, feline, canine, porcine and bovine. View All» Application Notes: Western Blot Analysis: 1:1000 dilution of a previous lot detected NEUROFILAMENT L on 10 μg of mouse brain lysates.Immunocytochemistry: A 1:200-1:500 dilution of a previous lot was used in IC.Optimal working dilutions must be determined by the end user. View All» Control: Brain tissue View All» Quality Assurance: Immunohistochemistry(paraffin) Analysis: Neurofilament-L (cat. # AB9568) staining on Normal Cerebellum. Tissue pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:800, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as fiber-like- staining (brown) around a Purkinje cells.Optimal Staining With EDTA Buffer, pH 8.0, Epitope Retrieval: Human Cerebellum View All» Purification Method: Unpurified View All» Presentation: Rabbit serum. Contains no preservative. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P07196 View All» Entrez Gene Number: NM_006158.2 View All» Gene Symbol:
  • NEFL

  • CMT1F

  • NF-L

  • NF68

  • CMT2E

  • NFL
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P07196 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.SIZE: 543 amino acids; 61517 Da DOMAIN: SwissProt: P07196 The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.PTM: O-glycosylated (By similarity).DISEASE: SwissProt: P07196 # Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is characterized by onset in infancy or childhood (range 1 to 13 years). & Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 2E (CMT2E) [MIM:607684]. CMT2E is an autosomal dominant form of Charcot-Marie-Tooth disease type 2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.SIMILARITY: Belongs to the intermediate filament family.MISCELLANEOUS: NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. View All» Brand Family: Chemicon View All» Product Name: Anti-Neurofilament L Antibody | AB9568 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Target / Localization: Cytoplasmic View All» Format: Serum View All» Host: Rabbit View All»
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