货号：AB9566

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Otx2 Antibody | AB9566 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody recognizes OTX2. The antibody will also react with OTX1 due to amino acid sequence homology between the two proteins. OTX2 is expressed earlier than OTX1 and therefore the antibody can be used to identify OTX2 during development. View All» Immunogen: Full length recombinant human OTX2 (excluding the first 5 amino acids). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:500-1:4,000. The antibody reacts with a doublet at 36 kDa in adult mouse retina extract. Immunohistochemistry: 1:500-1:4,000. Suggested fixative is 4% PFA-perfused or immersion fixed tissue. Suggested permeablization method is Triton X100 and blocking buffer is 5% serum in PBS. Suggested incubation time is overnight at 2-8°C. Immunocytochemistry Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P32243 View All» Entrez Gene Number:
  • NM_021728.2

  • NM_172337.1
    View All» Gene Symbol:
    • OTX2

    • MCOPS5

    • MGC45000
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P32243 # Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.SIZE: 289 amino acids; 31636 Da SUBCELLULAR LOCATION: Nucleus (Probable).TISSUE SPECIFICITY: Expressed in brain.DEVELOPMENTAL STAGE: Embryo.DISEASE: SwissProt: P32243 # Defects in OTX2 are the cause of syndromic microphthalmia 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities such as cardiac defects, facial clefts, microcephaly and hydrocephaly. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures.SIMILARITY: SwissProt: P32243 ## Belongs to the paired homeobox family. Bicoid subfamily. & Contains 1 homeobox DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Otx2 Antibody | AB9566 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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