货号：AB940

品牌：Merck Millipore

规格：

目录价：￥3896.00

市场价格：￥3311.60

会员价格：￥3116.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Growth Hormone Antibody | AB940 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Gives a positive and specific immunostaining of growth hormone-containing cells. View All» Background Information: ANTIGEN: Purified growth hormone View All» Species Reactivity:

• Canine

• Human

• Rat

• Sheep

• Feline

• Ox
  View All» Application Notes: Immunofluorescence and immunoperoxidase staining of formalin-fixed and paraffin-embedded sections of anterior pituitary glands. Cryostat sections of the same tissues can also be used.Optimal working dilutions must be determined by the end user.IMMUNOPEROXIDASE STAINING:1. Incubate the section with antiserum diluted 1:1000 - 1:2,000 in PBS at 37°C for 30 minutes.2. Wash for 15 minutes with PBS at room temperature and treat sequentially with Goat anti-Rabbit IgG and PAP complex at 37°C. Wash excess reagent from the section as described above.3. Treat the section with a mixture of 3,3'-diaminobenzidine HCl (0.02%) in hydrogen peroxide (0.004%). For preservation, the sections may be dehydrated, cleared and mounted.IMMUNOFLUORESCENCE STAINING:1. Same as Step 1 above.2. Incubate the section with antiserum diluted 1:20-1:40 in PBS at 37°C for 30 minutes.3. After washing off the excess antiserum with PBS, treat the section with fluorescein labeled Goat anti-Rabbit IgG for 30 minutes at 37°C. Wash the tissue with PBS and mount under glycerine-saline. View All» Presentation: Liquid rabbit serum. Contains 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P01241 View All» Entrez Gene Number:
  • NM_000515.3

  • NM_022559.2

  • NM_022560.2

  • NM_022561.2

  • NM_022562.2
    View All» Gene Symbol:
    • GH1

    • GH

    • GH-N

    • GHN

    • hGH-N
      View All» Alternate Names: GH View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunofluorescence

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. View All» UniProt Summary: FUNCTION: SwissProt: P01241 # Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.SIZE: 217 amino acids; 24847 Da SUBUNIT: Monomer, dimer, trimer, tetramer and pentamer, disulfide- linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.SUBCELLULAR LOCATION: Secreted.DISEASE: SwissProt: P01241 # Defects in GH1 are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which causes short stature. & Defects in GH1 are the cause of Kowarski syndrome [MIM:262650]; also known as pituitary dwarfism VI. & Defects in GH1 are a cause of isolated growth hormone deficiency type II (IGHD II) [MIM:173100]. IGHD II is an autosomal dominant deficiency of GH which causes short stature. & Defects in GH1 may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth.SIMILARITY: SwissProt: P01241 ## Belongs to the somatotropin/prolactin family.MISCELLANEOUS: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing." View All» Brand Family: Chemicon View All» Product Name: Anti-Growth Hormone Antibody | AB940 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Serum View All» Host: Rabbit View All»
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