货号：AB9372

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Necdin Antibody | AB9372 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Necdin. View All» Immunogen: Synthetic peptide from mouse Necdin. View All» Species Reactivity: Mouse View All» Application Notes: Immunoblotting: 0.5-1.0 μg/mL on mouse brain tissue homogenate. The antibody reacts with the ~43 kD Necdin protein. Additional bands at ~35 kD and ~60 kD may been seen depending on sample and antibody concentration used. Immunohistochemistry: 1:100 mouse cerebral cortex (second somatosensory cortex) using HIER (heat induced epitope retrieval). Recommend using citrate, pH 6.0. Optimal working dilutions must be determined by the end user. View All» Purification Method: Affinity Purfied View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q99608 View All» Entrez Gene Number: NM_002487.2 View All» Gene Symbol:

• NDN

• HsT16328

• necdin

• Necdin.
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. View All» UniProt Summary: FUNCTION: SwissProt: Q99608 # Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).SIZE: 321 amino acids; 36086 Da SUBUNIT: Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2 (By similarity).SUBCELLULAR LOCATION: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.TISSUE SPECIFICITY: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons.DISEASE: SwissProt: Q99608 # Defects in NDN may be a cause of the Prader-Willi syndrome (PWS) which is a contiguous gene syndrome resulting from inactivity of the paternal copies of a number of genes on 15q11, through deletion or disruption of these genes or maternal uniparental disomy 15. The PWS syndrome is characterized by muscular hypotonia, mental retardation, short stature, obesity, hypogonadotropic hypogonadism, and small hands and feet.SIMILARITY: SwissProt: Q99608 ## Contains 1 MAGE domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Necdin Antibody | AB9372 View All» Concentration: See lot specific C of A View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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