货号：AB81031

品牌：Merck Millipore

规格：

目录价：￥3896.00

市场价格：￥3311.60

会员价格：￥3116.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bone Morphogenetic Protein 1, CUB-2 Domain View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reactive with Bone Morphogenic protein-1 View All» Epitope: CUB-2 Domain View All» Immunogen: The antibody is made to a synthetic peptide based on the CUB-2 domain of the human sequence. View All» Background Information: Bone Morphogenetic protein-1 is an ubiquitous extracellular zinc endopeptidase of the Astacin family, which also includes Astacin, Meprin-A and B, Tolloid-like proteins and Choriolysin. The name BMP-1 reflects it's involvement in collagen deposition in growing bone. BMP-1 cleaves the carboxy end from procollagen, to allow formation of mature, triple-helical collagen. The amino-terminal end must also be cleaved by the Procollagen N-Proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP-1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP-1 have been reported, with varying truncation at the carboxy-terminal end. The long form of BMP-1 is most similar to the Tolloid-like proteins, which have extra EGF-like and CUB domains. View All» Species Reactivity: Human View All» Application Notes: Western blot: Starting dilutions 1:1000 for colorimetric substrates such as BCIP/NBT, 1:5000 for chemiluminescence substrates. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in PBS buffer, pH 7.4, with the addition of 0.01% sodium azide as preservative and 50% glycerol as cryoprotectant. View All» Storage Conditions: The undiluted antibody solution is stable for approximately 6 months at 40C. For longer storage, store at -200C. The solution is buffered from freezing at -20°C by 50% glycerol, but will freeze at -80°C. Avoid unnecessary freeze-thaw cycles. Diluted antibody can be reused several times if not contaminated; store at 40C with 0.05% Sodium Azide as preservative. View All» UniProt Number: P13497 View All» Entrez Gene Number:

• NM_001199.1

• NM_006128.1

• NM_006129.2
  View All» Gene Symbol:
  • BMP1

  • PCOLC

  • FLJ44432

  • BMP-1

  • TLD

  • PCP

  • mTld

  • EC 3.4.24.19
    View All» Alternate Names: BMP-1; PCP; ProCollagen C-Peptidase; Mammalian Tolloid Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region View All» UniProt Summary: FUNCTION: SwissProt: P13497 # Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SIZE: 986 amino acids; 111249 Da TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: P13497 ## Belongs to the peptidase M12A family. & Contains 5 CUB domains. & Contains 2 EGF-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Bone Morphogenetic Protein 1, CUB-2 Domain View All» Concentration: 1 mg/ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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