货号：AB6058

品牌：Merck Millipore

规格：50Ug

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Alpha Centractin (ARP1) Antibody | AB6058 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~44 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Alpha centractin. View All» Background Information: Alpha centractin is also known as actin related protein 1 (ARP1) is an important element of the dynactin complex which is thought to be involved in the organization of the centrosome and Golgi apparatus and determining nuclear nature with manchette microtubules during spermatid differentiation. It is essential for proper cytoskeleton formation and remodeling during mitosis and alpha-centractin under-expression has been found in the fetal down syndrome cortex. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected Alpha centractin in normal human seminal vesicle tissues. View All» Control: Human fetal skeletal muscle tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Alpha centractin in 10 µg of human fetal skeletal muscle tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P61163 View All» Entrez Gene Number: NP_005727 View All» Gene Symbol:
  • ACTR1A

  • CTRN1
    View All» Alternate Names:
    • Alpha-centractin

    • Centractin

    • ARP1

    • Actin-RPV

    • Centrosome-associated actin homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › centrosome. SEQUENCE SIMILARITIES: Belongs to the actin family. ARP1 subfamily. View All» Product Name: Anti-Alpha Centractin (ARP1) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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