货号：AB6050

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Kinesin-like protein KIF2A Antibody | AB6050 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Kinesin-like protein KIF2A at the C-terminus. View All» Molecular Weight: ~80 kDa observed. Uncharacterized bands appear at ~50, 55, and 70 kDa in some lysates. View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human Kinesin-like protein KIF2A. View All» Background Information: The kinesin-like protein KIF2A is a microtubule-depolymerizing KinK motor that stifles the elongation of axon collaterals and seems to be expressed in the centrosomes and spindle poles of cells during mitosis. KIF2A activity must balance MCAK activity to assure spindle bipolarity. Increased expression of KIF2A has been linked to an increase in progression, invasion and metastasis of squamous cell carcinoma of the oral tongue and may also be an indicator of patient prognosis. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunocytochemistry Analysis: A previous lot of this antibody detected KIF2A in the mitotic spindles and the spindle core of serum-starved HeLa cells. View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Kinesin-like protein KIF2A in 10 µg of NIH/3T3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00139 View All» Entrez Gene Number: NP_001091981 View All» Gene Symbol:
  • KIF2A

  • KIF2

  • KNS2
    View All» Alternate Names:
    • Kinesin-like protein KIF2A

    • Kinesin-2

    • hK2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. SUBUNIT STRUCTURE: Interacts with AURKA, PSRC1 and PLK1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle pole. Cytoplasm › cytoskeleton › spindle. Note: Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.MISCELLANEOUS: HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.SEQUENCE SIMLARITIES: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.Contains 1 kinesin-motor domain.SEQUENCE CAUTION: The sequence AAP84320.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Kinesin-like protein KIF2A View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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