货号：AB6008

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-9 Antibody, Hinge region | AB6008 View All» Replaces: AB16996 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes MMP-9 at the hinge region. View All» Molecular Weight: ~ 78 kDa. In Western Blot, this antibody recognizes bands at ~ 92 kDa (pro-form) and ~ 88 kDa (active form) on reducing gels. View All» Epitope: Hinge region View All» Immunogen: KLH-conjugated linear peptide corresponding to human MMP-9 at and around the hinge region. View All» Background Information: All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn2+ binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). MMP9, also known as gelatinase B, is a secreted enzyme which degrades the interstitial collagens, types I, II, and III and is produced by normal alveolar macrophages and granulocytes. View All» Species Reactivity:

• Human

• Chimpanzee

• Monkey
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee and monkey based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:100 dilution detected MMP-9 in breast cancer ductal carcinoma tissue.Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated MMP-9 in HL-60 RIPA cells. View All» Control: PMA-treated HL-60 concentrated media. View All» Quality Assurance: Evaluated by Western Blot using a PMA-treated HL-60 concentrated media.Western Blot Analysis: 5 µg/ml of this antibody detected MMP-9 in 10 µg of a PMA-treated HL-60 concentrated media. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P14780 View All» Entrez Gene Number: NP_004985.2 View All» Gene Symbol:
  • MMP9

  • CLG4B

  • GELB

  • MMP-9
    View All» Alternate Names:
    • 92 kDa gelatinase

    • 92 kDa type IV collagenase

    • Gelatinase B

    • macrophage gelatinase

    • matrix metallopeptidase 9

    • matrix metalloproteinase 9
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq] View All» UniProt Summary: FUNCTION: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond.COFACTOR: Binds 2 zinc ions per subunit. & Binds 3 calcium ions per subunit.SIZE: 707 amino acids; 78427 Da SUBUNIT: Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.TISSUE SPECIFICITY: Produced by normal alveolar macrophages and granulocytes.DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.SIMILARITY: Belongs to the peptidase M10A family. & Contains 3 fibronectin type-II domains. & Contains 4 hemopexin-like domains.MISCELLANEOUS: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status. View All» Product Name: Anti-MMP-9, Hinge region View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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