货号：AB6004

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MT1-MMP Antibody, hinge region | AB6004 View All» Replaces: AB815 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes human and rat MT1-MMP. It does not cross react with MMP-1, MMP-2, MMP-8, MMP-9, and MMP-13. View All» Molecular Weight: ~ 65 kDa View All» Epitope: Hinge region View All» Immunogen: KLH conjugated synthetic peptide selected from the hinge region of human MT1-MMP. View All» Background Information: Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes degrade the components of extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. MMPs play an important role in wound healing, apoptosis, bone elongation, embryo development, angiogenesis, cancer metastases, and tissue remodeling within many disease states.Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MT1-MMP (MMP-14) is a member of the membrane-type subfamily. Each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human and rat. Predicted to cross react with mouse, (95% sequence homology) and monkey chimpanzee, canine and bovine (100% sequence homology). Reactivity with other species has not been tested. View All» Control: Rat lung lysate. View All» Quality Assurance: Evaluated on a representative lot by Western blot on rat lung lysate using Anti-MT1-MMP. View All» Purification Method: Peptide affinity purified View All» Presentation: Purified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C for up to 1 year from date of receipt. View All» UniProt Number: P50281 View All» Entrez Gene Number: P50281 View All» Gene Symbol:
  • EC 3.4.24.80

  • MMP-14

  • MMP-X1

  • MT1-MMP

  • MT1MMP

  • MTMMP1
    View All» Alternate Names:
    • MT-MMP 1

    • Membrane-type matrix metalloproteinase 1

    • Membrane-type-1 matrix metalloproteinase

    • matrix metallopeptidase 14 (membrane-inserted)

    • matrix metalloproteinase 14

    • matrix metalloproteinase 14 (membrane-inserted)

    • membrane type 1 metalloprotease
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.CATALYTIC ACTIVITY: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.COFACTOR: Binds 1 zinc ion per subunit By similarity.Calcium By similarity.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The precursor is cleaved by a furin endopeptidase By similarity.SEQUENCE SIMILARITIES: Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains. View All» Product Name: Anti-MT1-MMP, hinge region View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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