货号：AB5976

品牌：Merck Millipore

规格：1ea

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dishevelled-2 Antibody | AB5976 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Dishevelled-2 protein (dvl-2). By Western blot the antibody shows no cross reactivity with recombinant dishevelled-1 (dvl-1) or dishevelled-3 (dvl-3) protein. Pre-adsorption of the antibody with the immunogen peptide completely abolishes its reactivity by Western blot against disheveiled-2 protein. View All» Immunogen: Synthetic peptide corresponding to amino acids 633-645 of human disheveiled-2 protein. View All» Background Information: DVL2 is a member of multigene family that also contains DVL1 and DVL3. The vertebrate dishevelled proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL2 encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1,000 using ECL. The antibody reacts with a protein of ~95kDa. Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody). Optimal working dilutions must be determined by end user. View All» Presentation: Partially purified immunoglobulin. Liquid in PBS, pH 7.4, containing 0.01M sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots (not less than 10 μL) for up to 6 months. Avoid repeated freeze/thaw cycles. The use of high quality antiserum-grade plastic or glass is recommended. View All» UniProt Number: O14641 View All» Entrez Gene Number: NM_004422.2 View All» Gene Symbol:

• DVL2

• Dishevelled-2
  View All» Alternate Names: DVL2; DSH Homolog 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. View All» UniProt Summary: FUNCTION: SwissProt: O14641 # May play a role in the signal transduction pathway mediated by multiple Wnt genes.SIZE: 736 amino acids; 78948 Da SUBUNIT: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts with DIXDC1 and Rac.SUBCELLULAR LOCATION: Cytoplasm.PTM: Phosphorylated.SIMILARITY: SwissProt: O14641 ## Belongs to the DSH family. & Contains 1 DEP domain. & Contains 1 DIX domain. & Contains 1 PDZ (DHR) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Dishevelled-2 Antibody | AB5976 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Purified View All» Host: Rabbit View All»
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