货号：AB5932

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel KvLQT1 Antibody, C-terminus | AB5932 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody recognizes Potassium Channel KvLQT1 protein. View All» Molecular Weight: ~ 72 kDa Observed View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide from the C-terminus of human KvLQT1. View All» Background Information: KvLQT1(Kv7.1) is a voltage-gated potassium channel protein coded for by the gene KCNQ1. This protein is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. KvLQT1 can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3 and in heart cells is required for the repolarization phase of the cardiac action potential. Mutations in the gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation, lead to a defective KvLQT1 protein and several forms of inherited arrhythmias known as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with rat and mouse based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Potassium Channel KvLQT1 in human myocardium tissue./Western Blotting Analysis: 2 μg/mL of thisantibody detected KvLQT1 in 10 μg of humanheart tissue lysate.Optimal working dilutions must be determined by end user. View All» Control: Human heart tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human heart tissue lysate.Western Blot Analysis: 2 µg/ml of this antibody detected KvLQT1 in 10 µg of human heart tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51787 View All» Entrez Gene Number: NP_000209.2 View All» Gene Symbol:
  • KCNQ1

  • JLNS1

  • ATFB1

  • SQT2

  • CNA8

  • LQT

  • WRS

  • Kv1.9

  • KVLQT1

  • RWS

  • Kv7.1

  • KCNA9

  • QTS

  • LQT1
    View All» Alternate Names:
    • IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1

    • KQT-like 1

    • Voltage-gated potassium channel subunit Kv7.1

    • kidney and cardiac voltage dependent K+ channel

    • potassium voltage-gated channel, KQT-like subfamily, member 1

    • slow delayed rectifier channel subunit
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described. View All» UniProt Summary: FUNCTION: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.SIZE: 676 amino acids; 74699 Da SUBUNIT: Heteromultimer with KCNE1 (MinK) or KCNE3 (MiRP2).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.DISEASE: Defects in KCNQ1 are the cause of long QT syndrome type 1 (LQT1) [MIM:192500]; also known as Romano-Ward syndrome (RWS). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. LQT1 inheritance is an autosomal dominant. & Defects in KCNQ1 are a cause of Jervell and Lange-Nielsen syndrome (JLNS) [MIM:220400]. JLNS is an autosomal recessive cardio-auditory syndrome characterized by a prolonged QT interval in the electrocardiogram and congenital deafness. & Defects in KCNQ1 are the cause of atrial fibrillation type 1 (ATFB1) [MIM:607554]. ATFB is characterized by rapid and irregular activation of the atrium. ATFB causes thromboembolism, tachycardia-mediated cardiomyopathy, heart failure and ventricular arrhythmia. & Defects in KCNQ1 are the cause of short QT syndrome type 2 (SQT2) [MIM:609621]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.SIMILARITY: Belongs to the potassium channel family. KQT subfamily.MISCELLANEOUS: Mutagenesis experiments were carried out by expressing in Xenopus oocytes or COS-7 cells KCNQ1 mutants either individually (homomultimers) or in combination with both wild-type KCNQ1 (mut/wt homomultimers) and minK (heteromultimers). View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel KvLQT1, C-terminus View All» Concentration: Lot specific View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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