货号：AB5832

品牌：Merck Millipore

规格：100Ug

目录价：￥5727.00

市场价格：￥4867.95

会员价格：￥4581.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BACE Antibody | AB5832 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human BACE by Western blot. View All» Immunogen: Synthetic peptide corresponding to amino acids 458 to 501 of human BACE (Vassar et al. 1999). View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blotting: 0.5-1.0 μg/mL on human brain tissue. The antibody recognizes a protein of molecular weight of 70 kDa in normal human brain lysate. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P56817 View All» Entrez Gene Number:
  • NM_012104.3

  • NM_138971.2

  • NM_138972.2

  • NM_138973.2
    View All» Gene Symbol:
    • BACE1

    • ASP2

    • beta-secretase

    • KIAA1149

    • Memapsin-2

    • BACE

    • memapsin-2

    • HSPC104

    • FLJ90568

    • EC 3.4.23.46
      View All» Alternate Names: ASP2; BACE1; Beta Secretase; beta-Site APP Cleaving Enzyme View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P56817 # Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.SIZE: 501 amino acids; 55764 Da SUBUNIT: Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Brain.SIMILARITY: SwissProt: P56817 ## Belongs to the peptidase A1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-BACE Antibody | AB5832 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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