货号：AB5701

品牌：Merck Millipore

规格：

目录价：￥4013.00

市场价格：￥3411.05

会员价格：￥3210.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Slit2 Antibody | AB5701 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Slit2 SUBCELLULAR LOCALIZATION: Membrane associated and cytoplasmic. View All» Immunogen: Synthetic peptide from human Slit2. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1,000 using ECL. The antibody reacts with proteins of ~200 kDa. Preferred gel percentage is 7.5%. Suggested blocking buffer is PBS containing 5% non-fat milk. Suggested dilution buffer is PBS containing 1% non-fat milk. Immunocytochemistry: 1:200 on cells fixed with 4% PFA for 30 minutes. Suggested permeablization method is 0.1% Triton X-100 for 5 minutes. Suggested blocking and incubation buffer is PBS containing 0.5% BSA. Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O94813 View All» Entrez Gene Number: NM_004787.1 View All» Gene Symbol:

• SLIT2

• Slit-2

• SLIL3

• FLJ14420
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» UniProt Summary: FUNCTION: SwissProt: O94813 # Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth- stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post- crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.SIZE: 1529 amino acids; 169870 Da SUBUNIT: Interacts with GREM1 (By similarity). Binds ROBO1 and ROBO2 with high affinity.SUBCELLULAR LOCATION: Secreted. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.TISSUE SPECIFICITY: Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.DOMAIN: SwissProt: O94813 The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 7 EGF-like domains. & Contains 1 laminin G-like domain. & Contains 23 LRR (leucine-rich) repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Slit2 Antibody | AB5701 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Secreted View All» Format: Serum View All» Host: Rabbit View All»
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