货号：AB5682

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurogenin-2 Antibody | AB5682 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Neurogenin 2 (MATH4a), a Helix-loop-helix class of transcription factor. View All» Molecular Weight: ~28 kDa View All» Immunogen: Synthetic peptide, amino acids 85-97 of mouse Neurogenin 2. View All» Isotype: IgG View All» Background Information: Neurogenin 2 (NGN2) is a helix-loop-helix class of transcription factor. Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors, including Neurogenin 2 and a decrease in the activity of Hes and Id factors. bHLH factors have key roles in corticogenesis, affecting the timing of differentiation and the specification of cell fate. Neurog2 controls neurogenesis in the embryonic cerebral cortex directly induces the expression of the small GTP-binding protein Rnd2 in newly generated mouse cortical neurons before they initiate migration. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1-10 μg/mL using ECL. Immunocytochemistry: Cat. # AB5682 detected Neurogenin-2 in PC12 cells at 1:500 dilution. It was also detected in paraformaldehyde-fixed differentiated human neural stem cells.ELISA: 0.5-1 μg/mL using 1 mg/mL control peptide (Catalog Number AG352) per well. Immunohistochemistry on paraffin sections has been reported by Lamolet, B. et al. (2004) Optimal working dilutions must be determined by the end user. View All» Control: Human brain Lysate. View All» Presentation: Affinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q9H2A3 View All» Entrez Gene Number: NM_024019.2 View All» Gene Symbol:
  • NEUROG2

  • ATOH4

  • ngn-2

  • NGN2

  • MGC46562

  • Math4A

  • Atoh4

  • Neurogenin-2
    View All» Alternate Names: MATH4a (ms); ATH 4a; Atoh4; Ngn2; Atonal Protein Homolog 4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» Entrez Gene Summary: Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9H2A3 # Involved in neurogenesis (By similarity).SIZE: 272 amino acids; 28621 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity).SUBCELLULAR LOCATION: Nucleus (Potential).SIMILARITY: SwissProt: Q9H2A3 ## Contains 1 basic helix-loop-helix (bHLH) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Neurogenin-2 Antibody | AB5682 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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