货号：AB5656P

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histamine Receptor 2 Antibody, C-terminus | AB5656P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes rat Histamine Receptor 2 (HR2). The immunogen shows no significant sequence homology with other histamine receptors. SPECIES REACTIVITIES: The immunogen peptide is 100% conserved in mouse. No significant homology with human HR2. Reactivity with other species has not been confirmed. View All» Epitope: C-terminus View All» Immunogen: A 14 amino acid peptide sequence within the cytoplasmic, C-terminus of rat HR2 (Ruat et al. 1991; Kobayashi et al. 1996; Murakami et al. 1999; Ganz et al. 1991; Nihsi et al. 1995; Orange et al. 1996). View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: 1-10 μg/mL using ECL. Recognizes a ~69kDa band in reducing westerns. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5, containing 0.2% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P25021 View All» Entrez Gene Number: NM_022304.1 View All» Gene Symbol:
  • HRH2

  • DDX15

  • DBP1

  • H2R
    View All» Alternate Names: H2R View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. View All» UniProt Summary: FUNCTION: SwissProt: P25021 # The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).SIZE: 359 amino acids; 40098 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: P25021 ## Belongs to the G-protein coupled receptor 1 family.MISCELLANEOUS: Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease. View All» Brand Family: Chemicon View All» Product Name: Anti-Histamine Receptor 2 Antibody, C-terminus | AB5656P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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