货号：AB5622

品牌：Merck Millipore

规格：100UL

目录价：￥6895.00

市场价格：￥5860.75

会员价格：￥5516.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Microtubule-Associated Protein 2 (MAP2) Antibody | AB5622 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for Microtubule-associated protein 2 (MAP2). The antibody recognizes all MAP2 isoforms (MAP2A, MAP2B, MAP2C and MAP2D). It shows greatest immunoreactivity with the HMW-MAP2 (MAP2A and MAP2B). View All» Molecular Weight: Approx. 280 kDa doublet (MAP2a and MAP2b) and approx. 70 kDa doublet (MAP2c) on SDS-PAGE. View All» Immunogen: Purified Microtubule-associated protein from rat brain. View All» Background Information: The microtubule-associated protein 2 (MAP2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). In neurons MAP2 occurs as three primary isoforms, the high molecular weight MAP2a, MAP2b, and the low molecular weight MAP2c, that result from alternative splicing of the MAP2 gene (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP2 together with MAP4 and tau proteins belong to the family of thermostable proteins associated with microtubules. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse and rat. Reactivity with other species has not been determined. View All» Application Notes: Immunocytochemistry: 1:1,000 dilution of a previous lot was used on primary neurons.Immunohistochemistry: 1:1,000 dilution on 4% paraformaldehyde / PBS fixed tissue sections.Immunoblot:1:2,000 dilution was used on a previous lot. Recognizes MAP2A (280-300kDa, and MAP2B (270-280KDa), and to a lesser extent MAP2C (70kDa) and MAP2D (70-75kDa). ELISA: greater than or equal to1:2,000 dilution of a previous lot was used.Optimal working dilutions must be determined by the end user. View All» Control: Human brain tissue or human glioblastoma T98G cells View All» Quality Assurance: Immunohistochemistry(paraffin) Analysis: MAP2 (cat. # AB5622) staining on Normal Cerebellum. Tissue pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:500, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as fiber-like- staining (brown) on microtubule.Optimal Staining With TE Buffer, pH 9.0, Epitope Retrieval: Human Cerebellum View All» Purification Method: Ammonium sulfate precipitation View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.1% sodium azide as a preservative. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P11137 View All» Entrez Gene Number: NM_001039538.1 View All» Gene Symbol:
  • MAP2

  • MAP2B

  • MAP-2

  • MAP2C

  • DKFZp686I2148

  • MAP2A
    View All» Alternate Names: microtubule-associated protein 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.SIZE: 1827 amino acids; 199539 Da PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: P11137 ## Contains 3 Tau/MAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Microtubule-Associated Protein 2 (MAP2) Antibody | AB5622 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: All neurons, Cytoplasmic, soma, dendritic View All» Format: Purified View All» Host: Rabbit View All»
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