货号：AB5604-200UL

品牌：Merck Millipore

规格：1SA

目录价：￥10062.00

市场价格：￥8552.70

会员价格：￥8049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type | AB5604-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes alpha2/delta-1 subunit, N-terminal. The epitope does not share homology with any other known proteins. By sequence comparsions, the epitope sequence used is identical in human, porcine, with mouse and rat missing only a single amino acid. Reactivity has been verified only in rat membranes. View All» Epitope: Voltage Gated alpha 2/delta-1,L-type View All» Immunogen: Peptide corresponding to 15 amino acids from the rabbit alpha2 subunit (residues 27-41 of rabbit alpha2/delta-1 precursor) P13806 View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:200 using ECL on rat brain membranes. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 0.75 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 L of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P54289 View All» Entrez Gene Number: NM_000722.2 View All» Gene Symbol:

• CACNA2D1

• CACNA2

• CACNL2A

• H_DJ0560O14.1

• CCHL2A

• MHS3

• WUGSC:H_DJ0560O14.1
  View All» Alternate Names: Cacna2d1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: P54289 # The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).SIZE: 1091 amino acids; 123183 Da SUBUNIT: Dimer formed of alpha-2-1 and delta-1 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).TISSUE SPECIFICITY: Central nervous system, skeletal muscle and aorta tissues.DOMAIN: SwissProt: P54289 The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity).PTM: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked (By similarity).SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta family. & Contains 1 cache domain. & Contains 1 VWFA domain.MISCELLANEOUS: Binds gabapentin, an antiepileptic drug." View All» Brand Family: Chemicon View All» Product Name: Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type | AB5604-200UL View All» Concentration: 80 μg/200 μL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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