货号：AB5603

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sox2 Antibody | AB5603 View All» Replaces: AB5770 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Transcription factor Sox2. On western blots of whole cell or nuclear extracts, the antibody recognizes a 34 kDa band corresponding to Sox2 that is not observed in cytosolic extracts. View All» Molecular Weight: 34 kDa View All» Immunogen: Synthetic peptide corresponding to human Sox2 (Acc# P48431). The immunogen sequence is identical in human and mouse. View All» Background Information: SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: 0.5-1.0 μg/mL on mouse ES cell or human NT2/D1 cell extracts. Reacts with a band of ~34 kDa. At higher antibody concentrations, may also react with bands of ~45 kDa and ~52 kDa (unknown origin). The 34 kDa Sox2 band is not observed on western blots of cytosolic extracts. Immunocytochemistry: 1:1,000 using a Cy3 conjugated secondary antibody (AP132C) on mouse ES cells. Optimal working dilutions must be determined by the end user. View All» Control: Immunoblot: Mouse or human embryonic stem cell lysate, mouse embryonic germ cell lysateImmunocytochemistry: Human embryonic stem cells (H9 line) View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH7.4. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P48431 View All» Entrez Gene Number: NM_003106.2 View All» Gene Symbol:
  • SOX2

  • ANOP3

  • MGC2413

  • MCOPS3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). View All» UniProt Summary: FUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).SIZE: 317 amino acids; 34310 Da SUBCELLULAR LOCATION: Nucleus.DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Sox2 Antibody | AB5603 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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