货号：AB5600-50UL

品牌：Merck Millipore

规格：50UL

目录价：￥4884.00

市场价格：￥4151.40

会员价格：￥3907.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Synaptotagmin I Antibody, luminal part | AB5600-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Synaptotagmin I, luminal part. The epitope does not share homology with any other known proteins. SPECIES REACTIVITIES: It is expected that the antibody will also recognize human. Other species have not been tested. View All» Epitope: luminal part View All» Immunogen: Peptide corresponding to amino acids 1-19 from rat Synaptotagmin I (Accession # P21107). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:200-1:1,000 using ECL on rat brain membranes. Immunohistochemistry on rat brain sections. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P21579 View All» Entrez Gene Number: NM_005639.1 View All» Gene Symbol:

• SYT1

• DKFZp781D2042

• SVP65

• SytI

• SYT

• p65

• P65

• Synaptotagmin-1
  View All» Alternate Names: p65; Syt1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P21579 # May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity).SIZE: 422 amino acids; 47573 Da SUBUNIT: Homotetramer (Probable). Interacts with STN2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity).SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note=Synaptic vesicles and chromaffin granules.DOMAIN: SwissProt: P21579 The first C2 domain mediates Ca(2+)-dependent phospholipid binding. & The second C2 domain mediates interaction with SV2A and STN2 (By similarity).SIMILARITY: Belongs to the synaptotagmin family. & Contains 2 C2 domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Synaptotagmin I Antibody, luminal part | AB5600-50UL View All» Concentration: 10 μg/50 μL (after reconstitution). View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Target / Localization: Presynaptic View All» Format: Affinity Purified View All» Host: Rabbit View All»
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