货号：AB5597

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel KCNQ3 Antibody | AB5597 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for KCNQ3. View All» Immunogen: Fusion protein from KCNQ3 View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:500-1:2,000. Suggested blocking buffer is 5% non-fat dry milk with 0.05% Tween 20 in PBS. Expected molecular weight is approximately 97 kDa on transfected cells. An additional band of approximately 200 kDa can also been seen. On rat brain extract the antibody recognizes a protein of approximately 140-165 kDa. Immunocytochemistry: 1:1,000 on transfected HEK293 cell line. Suggested fixative is 4% paraformaldehyde in PBS. Suggested blocking buffer 3% goat serum, 1% BSA, 0.25% Triton X100 in PBS. Immunoprecipitation Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. View All» UniProt Number: O43525 View All» Entrez Gene Number: NM_004519.2 View All» Gene Symbol:
  • KCNQ3

  • BFNC2

  • Kv7.3

  • EBN2

  • BFNC

  • KV7.3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). View All» UniProt Summary: FUNCTION: SwissProt: O43525 # Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.SIZE: 872 amino acids; 96742 Da SUBUNIT: Heteromultimer with KCNQ2 or KCNQ5. May associate with KCNE2.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Predominantly expressed in brain.DOMAIN: SwissProt: O43525 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity).DISEASE: SwissProt: O43525 # Defects in KCNQ3 are the cause of benign familial neonatal convulsions type 2 (BFNC2) [MIM:121201]; also known as epilepsy, benign neonatal type 2 (EBN2). BFNC2 is an autosomal dominant form of epilepsy in the newborn that clears spontaneously after a few weeks and is followed by normal psychomotor development.SIMILARITY: Belongs to the potassium channel family. KQT subfamily.MISCELLANEOUS: Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ3(mut) and KCNQ2 at the ratio of 1:1, or of KCNQ3(mut), KCNQ3(wt) and KCNQ2 at the ratio of 1:1:2, to mimic the situation in a heterozygous patient with BFNC2 disease. View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel KCNQ3 Antibody | AB5597 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-158102.htm
      © Merck Millipore代理AB5597 KCNQ3, RBX-50UL;已停产，产品报价联系微信jinshanbio