货号：AB5590

品牌：Merck Millipore

规格：EA

目录价：￥4780.00

市场价格：￥4063.00

会员价格：￥3824.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nicotinic Acetylcholine Receptor α4 Antibody | AB5590 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Nicotinic Acetylcholine Receptor alpha4 (nAChR alpha4). The antibody stains nerve fibers and cell bodies in untreated animals. The staining pattern for the immunoreactive cell bodies obtained with AB5590 corresponds to the pattern described using in situ hybridization with probes to rat nAChR receptor mRNA. (Wada et al., 1989, 1990; Duvoisin et al., 1989; Dineley-Miller and Patrick, 1992; Seguela et al., 1993) as well as using antisera to nAChR (Mason, 1985; Swanson et al., 1987; Schroder et al., 1989; Bravo and Karten, 1992; Okuda et al., 1993; Dominguez del Toro et al., 1994; Nakayama et al., 1995; Goldner et al., 1997; Rogers et al., 1998; Sorenson et al., 1998; Arroyo-Jiménez et al., 1999). Strong nAChR a4 immunoreactivity is demonstrated in the Purkinje cells of the cerebellum, in neurons of the cerebral cortex, striatum, brainstem and spinal cord. SPECIES REACTIVITIES: It is expected that the antibody will also react with mouse and human based on sequence homology. Other species have not yet been tested. View All» Immunogen: Synthetic peptide corresponding to amino acids 568-588 of the rat nAChR alpha4 protein. View All» Species Reactivity: Rat View All» Application Notes: Immunohistochemistry: 1:1,000-1:2,000 using a Cy3 conjugated secondary antibody. The tissue was fixed in a paraformaldehyde/picric acid-mixture (4% paraformaldehyde and 0.4% picric acid in 0.16 M sodium phosphate buffer, pH 6.9). See application notes on back page. Western blot: not tested Optimal working dilutions must be determined by end user. View All» Presentation: Guinea pig serum. Liquid. Contains no preservative. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P43681 View All» Entrez Gene Number: NM_000744.3 View All» Gene Symbol:

• CHRNA4

• NACRA4

• BFNC

• ENFL1

• EBN

• EBN1
  View All» Alternate Names: nAChRalpha4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors respond by undergoing an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene appear to account for a small proportion of the cases of nocturnal frontal lobe epilepsy. View All» UniProt Summary: FUNCTION: SwissProt: P43681 # After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.SIZE: 627 amino acids; 69957 Da SUBUNIT: Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta- 2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.DISEASE:SwissProt: P43681 # Defects in CHRNA4 are the cause of autosomal dominant nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is a disease characterized by clusters of motor seizures during sleep.SIMILARITY: SwissProt: P43681 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Nicotinic Acetylcholine Receptor α4 Antibody | AB5590 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Guinea Pig View All»
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