货号：AB5539

品牌：Merck Millipore

规格：50UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurofilament H Antibody | AB5539 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Neurofilament-Heavy (NF-H). The antibody stains sharply defined cytoplasmic filaments in neuronal cell bodies and especially axons. View All» Molecular Weight: 200 kDa View All» Immunogen: Purified bovine NF-H. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Pig

• Rat

• Feline
  View All» Application Notes: Western blot: 1:1,000-1:10,000 using ECL. Recognizes a band of 200-220 kDa. Immunohistochemistry: 1:1,000-1:10,000 on frozen or paraffin embedded tissue sections. Suggested fixative is 4% paraformaldehyde. Immunocytochemistry: 1:1,000-1:10,000 on cells in tissue culture fixed for one minute in 3.7% formalin and one minute in -20°C methanol. Optimal working dilutions must be determined by the end user. View All» Control: Positive control: brain. Negative control: kidney, liver. View All» Purification Method: Ammonium sulfate precipitation View All» Presentation: Purified chicken IgY in PBS containing 5mM sodium azide. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P12036 View All» Entrez Gene Number: NM_021076.2 View All» Gene Symbol:
  • NEFH

  • NF-H

  • NFH

  • KIAA0845
    View All» Alternate Names: NF-H View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P12036 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.SIZE: 1026 amino acids; 112480 Da PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.DISEASE: SwissProt: P12036 # Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.SIMILARITY: SwissProt: P12036 ## Belongs to the intermediate filament family. View All» Brand Family: Chemicon View All» Product Name: Anti-Neurofilament H Antibody | AB5539 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μL View All» Format: Purified View All» Host: Chicken View All»
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