货号：AB5535

品牌：Merck Millipore

规格：100Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sox9 Antibody | AB5535 View All» Replaces: AB5809 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Sox9. View All» Molecular Weight: 56-65 kDa View All» Immunogen: Synthetic peptide from human Sox9. View All» Background Information: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, rat and fetal mouse. Other species have not yet been tested. View All» Application Notes: Western Blot:1:500 dilution of a previous lot ~65kDa band EMSA supershift Optimal working dilutions must be determined by the end user. View All» Control: Embryonic tissue, Adult chondrocytes. View All» Quality Assurance: Routinely evaluated by Western Blot on L6 cell lysates.Western Blot Analysis: 1:2000 dilution of this lot detected SOX-9 on 10 μg of L6 cell lysate View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt. View All» UniProt Number: P48436 View All» Entrez Gene Number: NP_000337 View All» Gene Symbol:
  • SOX9

  • CMPD1

  • CMD1

  • SRA1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. View All» UniProt Summary: FUNCTION: SwissProt: P48436 # Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.SIZE: 509 amino acids; 56137 Da SUBCELLULAR LOCATION: Nucleus (Potential).DISEASE: SwissProt: P48436 # Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male- to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.SIMILARITY: SwissProt: P48436 ## Contains 1 HMG box DNA-binding domain View All» Brand Family: Chemicon View All» Product Name: Anti-Sox9 Antibody | AB5535 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: Early marker of cranial neural crest derived chondrocytes View All» Format: Affinity Purified View All» Host: Rabbit View All»
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