货号：AB5491-200UL

品牌：Merck Millipore

规格：200UL

目录价：￥8226.00

市场价格：￥6992.10

会员价格：￥6580.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium Channel Cav3.1 Antibody | AB5491-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Cav3.1. The epitope specific for Cav3.1 is not present in any other known proteins. SPECIES REACTIVITIES: The immunogen sequence is conserved in human (20/22). Reactivity with other species has not yet been tested. View All» Immunogen: Highly purified peptide corresponding to residues 1-22 of rat Cav3.1 (Accession O54898). View All» Species Reactivity: Rat View All» Application Notes: Western blotting: 1:200 using ECL on rat brain membranes. See suggested protocol. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Control: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, 5% sucrose and 0.05% sodium azide. Reconstitute with 200 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 6 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O43497 View All» Entrez Gene Number:

• NM_018896.3

• NM_198376.1

• NM_198377.1

• NM_198378.1

• NM_198379.1

• NM_198380.1

• NM_198382.1

• NM_198383.1

• NM_198384.1

• NM_198385.1

• NM_198386.1

• NM_198387.1

• NM_198388.1

• NM_198396.1

• NM_198397.1
  View All» Gene Symbol:
  • CACNA1G

  • Ca(V)T.1

  • KIAA1123

  • Cav3.1

  • Cav3.1c

  • NBR13

  • MGC117234
    View All» Alternate Names: T-type Alpha 1G View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Voltage-activated calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. See MIM 601011. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: O43497 # Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.SIZE: 2377 amino acids; 262472 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.DOMAIN: SwissProt: O43497 Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. & The linker region between repeat III and IV probably play a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion.PTM: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.SIMILARITY: Belongs to the calcium channel alpha-1 subunit family. View All» Brand Family: Chemicon View All» Product Name: Anti-Calcium Channel Cav3.1 Antibody | AB5491-200UL View All» Concentration: 0.8 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-158056.htm
    © Merck Millipore代理AB5491-200UL Anti-Calcium Channel Cav3.1 Antibody;store at -20℃，产品报价联系微信jinshanbio