货号：AB5443

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tropomyosin Antibody, 9a containing | AB5443 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Tropomyosin splice variants containing exon 9a. View All» Epitope: 9a containing View All» Immunogen: Synthetic peptide corresponding to the 9a exon from the gamma gene of tropomyosin. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western Blot: 1:50-1:500. Immunocytochemistry: 1:50-1:500 Immunohistochemistry: 1: 1:50-1:500 Optimal working dilutions must be determined by the end user. View All» Presentation: Unpurified serum in PBS (liquid). View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P06753 View All» Entrez Gene Number:
  • NM_001043351.1

  • NM_001043352.1

  • NM_001043353.1

  • NM_152263.2

  • NM_153649.3
    View All» Gene Symbol:
    • TPM3

    • TM30

    • MGC3261

    • TRK

    • NEM1

    • TM30nm

    • FLJ41118

    • Tropomyosin-3

    • OK/SW-cl.5

    • TM-5

    • hscp30

    • TPMsk3

    • MGC14582

    • hTM5

    • TM3

    • MGC72094
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P06753 # Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.SIZE: 284 amino acids; 32819 Da SUBUNIT: Heterodimer of an alpha and a beta chain. Binds to TMOD1.DOMAIN: SwissProt: P06753 The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.DISEASE: SwissProt: P06753 # Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1) [MIM:609284]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity. NEM1 inheritance is autosomal dominant. & A chromosomal aberration involving TPM3 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.SIMILARITY: Belongs to the tropomyosin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Tropomyosin Antibody, 9a containing | AB5443 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Sheep View All»
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