货号：AB5436P

品牌：Merck Millipore

规格：50Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Brain and Muscle ARNT-Like 1 Antibody | AB5436P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes drosophila BMAL1. The immunogen shows no significant sequence homology with mammalian Clock or Per proteins. Significant homology is seen with mammalian USF's (Upstream Stimulatory Factors 1 and 2) and human and mouse BMAL1 and ARNTs. SPECIES REACTIVITIES: The immunogen sequence has no homology with mammalian Clock or Per proteins. Reactivity with other species has not been confirmed. View All» Immunogen: A 22 amino acid peptide of drosophila BMAL1 (Darlington et al. 1998; Rutila et al. 1998; Bae et al. 1998). Gene accession # 3219728. View All» Species Reactivity: Drosophila View All» Application Notes: Western blot: 1-10 μg/mL using ECL. ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O00327 View All» Entrez Gene Number:

• NM_001030272.1

• NM_001030273.1

• NM_001178.4
  View All» Gene Symbol:
  • ARNTL

  • BMAL1

  • MOP3

  • BMAL1c

  • TIC

  • PASD3

  • JAP3

  • MGC47515
    View All» Alternate Names: BMAL1; MOP3/CYCLE View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: O00327 # BMAL1-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).SIZE: 626 amino acids; 68762 Da SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Highly expressed in the adult brain, skeletal muscle and heart.PTM: Phosphorylated upon dimerization with CLOCK (By similarity). & Sumoylated on Lys-259 upon dimerization with CLOCK (By similarity).SIMILARITY: SwissProt: O00327 ## Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 2 PAS (PER-ARNT-SIM) domains. MISCELLANEOUS: CLOCK-BMAL1 double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity. View All» Brand Family: Chemicon View All» Product Name: Anti-Brain and Muscle ARNT-Like 1 Antibody | AB5436P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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