金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Pappalysin-1/PAPP-A Long Name: Pregnancy-associated Plasma Protein 1 Aliases: ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPPA; PAPP-A1 Entrez Gene IDs: 5069 (Human) Background: Pappalysins Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.