金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:Bead-based multiplex assay for the Luminex® platform Assay Format:96-well microplate and antibody-coated beads* Analytes Detected:Please see table below. Additional Performance Validation:For standard curves, intra-assay and inter-assay precision, recovery, and linearity data for the different analyte-specific beads, please see product datasheets for corresponding individual Bead Sets (below). Molecule Information: CCL3/MIP-1 alpha Aliases: LD78a; MIP-1 alpha Entrez Gene IDs: 6348 (Human); 20302 (Mouse); 25542 (Rat); 448787 (Canine) Background: CCL3/MIP-1 alpha

The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.