产品英文名称：Jagged-1 Fc fusion protein

产品中文名称：Jagged-1 Fc 融合蛋白

Jagged-1 Fc fusion protein产品介绍：

最初在果蝇神经系统发育的研究中发现Notch信号途径的功能。Notch信号通路是进化中高度保守的信号转导通路，其调控细胞增殖、分化和凋亡的功能几乎涉及所有组织和器官。该通路由Notch受体、配体和CSL蛋白3部分组成。

Jagged-1是notch 配体的受体，是DSL蛋白家族，分子量为180kda的一种蛋白。

Jagged-1 Fc fusion protein产品纯度高，通过human 293 cell纯化得到，并经过SDS-PAGE 鉴定纯度大于90%。生物活性经过Notch通路报告基因检测，The EC50为200–1000 ng/mL.

Jagged-1 Fc fusion protein产品英文简述：

The Notch pathway is an important pathway in stem cell functions. Jagged-1, a ligand for Notch receptors, is a 180kDa type 1 membrane glycoprotein of the Delta/Serrate/Lag2 (DSL) family.

StemRD’s Jagged-1 Fc fusion protein is expressed in human 293 cells as the 1046aa N-terminal extracellular domain of Jagged-1 fused to the Fc domain of human IgG1. This fusion stabilizes Jagged-1 in vitro and in vivo without significant compromise in its biological activity.

• Purity：Greater than 90% as determined by SDS-PAGE analysis

• Biological Activity：Determined by a Notch pathway specific reporter gene assay. EC50s are in the range of 200 – 1000 ng/mL.