产品英文名称：JAG-1 protein active peptide fragment

产品中文名称：JAG-1 蛋白活性片断

JAG-1 protein active peptide fragment产品介绍：

最初是在果蝇神经系统发育的研究中发现Notch信号途径的功能。Notch信号通路是进化中高度保守的信号转导通路，其调控细胞增殖、分化和凋亡的功能几乎涉及所有组织和器官。该通路由Notch受体、配体和CSL蛋白3部分组成。

Jagged-1是notch 配体的受体，这种肽序列CDDYYYGFGCNKFCRPR能模拟全长Jagged-1的功能，作为激动剂激活Notch 信号通路。

JAG-1 protein active peptide fragment产品纯度高，通过RP-HPLC鉴定纯度大于95%。

JAG-1 protein active peptide fragment产品英文简述：

The Notch pathway is an important pathway in stem cell functions. Jagged-1 is a ligand for Notch receptors. This peptide with a sequence of CDDYYYGFGCNKFCRPR has been shown to mimic the function of full-length Jagged-1, and therefore, can be used as an agonist to activate the Notch pathway.

Ref: Nickoloff et al, Cell Death Different, 2002; Sato T et al, Nature, 2009

• Stability：The lyophilized protein is stable for at least 1 year if stored at -80 degree C. Reconstituted protein is stable for at least 1 month at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw

• Purity：Greater than 95% as determined by RP-HPLC analysis