产品英文名称：LY364947

产品中文名称：LY364947

LY364947产品英文简述：

LY364947 is a selective inhibitor of TGF-beta type-I receptor (IC50 59 nM for TGF-beta RI vs. 400 nM for TGF-beta RII). [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole

Ref: Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J. Med. Chem. 46 3953, 2003.

• Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

• Biological Activity: In a cell-based assay measuring the activation of a SMAD reporter gene, this compound gives IC50 around 100-200 nM.