产品英文名称：Follistatin Fc Fusion, huamn

产品中文名称：人Follistatin Fc Fusion分泌蛋白

Follistatin Fc Fusion, huamn产品介绍：

Follistatin是一类与某些TGF-β家族成员相关并阻止其与相关受体相联系的分泌蛋白。除了是Activins的天然拮抗物外，Follistatin可能会抑制其它诸如BMPs，Myostatin，GDF-11和TGF-β1等TGF-β配合基的生物活性。

StemRD的Follistatin Fc融合蛋白是由全片段的人Follistatin-288与N-端基的人IgG1 Fc片段融合而产生的。这种融合保证了体内外蛋白的稳定性，以及重组蛋白二聚体对Activins的高亲和性。

用无血清无蛋白的培养基培养人293细胞，看其基因表达情况。使用蛋白A色谱分析法对特定培养基条件下的融合蛋白进行纯化。

Follistatin Fc Fusion, huamn产品特性：

» Follistatin Fc Fusion, huamn经SDS-PAGE鉴定纯度大于95%

» 生物活性在培养人体细胞中使用SMAD受体基因检测确定，在2ng/mL激活素A活性抑制下IC50达20 - 100 ng/ml

» 本产品只限于科学研究，非人体使用

Follistatin Fc Fusion, huamn产品英文简述：

Follistatin is a secreted protein that binds to some members of the TGF-β family and blocks their access to corresponding receptors. In addition to being a natural antagonist of Activins, follistatin can inhibit the activity of other TGF-β ligands including BMPs, Myostatin, GDF-11, and TGF-β1. StemRD's Follistatin Fc fusion protein is full-length human Follistain-288 fused to the N-terminus of the Fc domain of human IgG1. This fusion allows stabilization of the protein in vitro and in vivo and dimerization of the recombinant protein rendering high-affinity binding to Activins. Expression is in human 293 cells cultured in serum-free and protein-free medium. Purification of the fusion protein from culture medium is achieved by using protein A chromatography.

• Purity: Greater than 95% as determined by SDS-PAGE analysis

• Biological Activity: The activity was determined by using a SMAD reporter gene assay in cultured human cells. The IC50 ranges from 20 - 100 ng/ml in the inhibition of 2 ng/mL Activin A activity

• For Research Use Only. Not for Use in Human