产品英文名称: BMP-4,human

产品中文名称:人骨形态发生蛋白4

BMP-4,human产品介绍：

属于TGF-β超家族的骨形态发生蛋白4(bone morphogenetic protein 4, BMP4)具有促进肿瘤发生及侵袭转移的作用，在多种恶性肿瘤组织中表达增加。近年来许多研究表明BMPs不仅能诱导成骨，而且对靶细胞的生长、分化以及凋亡具有调控作用，BMP4是BMPs中诱导成骨等生物学活性最强的分子之一，人们发现其在多种肿瘤中表达异常，虽然将其应用于临床中还存在一些需要解决的问题，但随着研究的深入，BMP4在发病机理、识别治疗靶点、预测疗效等方面应用前景将更加广阔。

» 生物活性在人源293细胞经过SMAD实验鉴定The EC50为 1.0–5.0 ng/ml

» BMP-4产品经过SDS-PAGE 和HPLC双层鉴定纯度大于95%

» BMP-4活性经过人源细胞鉴定，纯度高

» 只限于科学研究，非人体使用

BMP-4,human产品英文简述：

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-family of structurally related signaling proteins. BMP-4 is involved in the development and maintenance of bone and cartilage. Recombinant human BMP-4, expressed in mammalian cells, is a 32-38 kDa homodimeric glycoprotein. StemRD’s BMP-4 is made in human 293 cells, which renders human-specific post-translational modifications. We purified this product through a series of chromatography including HPLC.

• Purity: Greater than 95% by SDS-PAGE and HPLC analysis

• Biological Activity: The activity was determined by using a BMP response element (BRE) reporter gene assay. The EC50 ranges from 1 – 5 ng/ml.

• For Research Use Only. Not for Use in Humans.