货号：AB5246-50UL

品牌：Merck Millipore

规格：1EA

目录价：￥4625.81

市场价格：￥3931.94

会员价格：￥3700.65

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-P2X7 Receptor Antibody | AB5246-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The epitope is specific for P2X7 and is not present in any other known protein. View All» Immunogen: Purified peptide P2X7 from 576-595 of rat P2X7 (Accession Q64663). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:200-1:300 using ECL on rat brain membranes. Immunohistochemistry: rat brain sections. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q99572 View All» Entrez Gene Number: NM_002562.4 View All» Gene Symbol:

• P2RX7

• MGC20089

• P2X7
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» Entrez Gene Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. View All» UniProt Summary: FUNCTION: SwissProt: Q99572 # Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.SIZE: 595 amino acids; 68559 Da SUBUNIT: Forms homo- or heteropolymers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.PTM: Phosphorylation results in its inactivation.SIMILARITY: SwissProt: Q99572 ## Belongs to the P2X receptor family. View All» Brand Family: Chemicon View All» Product Name: Anti-P2X7 Receptor Antibody | AB5246-50UL View All» Concentration: 0.6 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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