货号：AB5202-200UL

品牌：Merck Millipore

规格：1SA

目录价：￥8171.00

市场价格：￥6945.35

会员价格：￥6536.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel IsK Antibody | AB5202-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a full length IsK protein. Does not cross react with any other potassium channel antigens tested so far. View All» Immunogen: GST fusion protein from the C-terminal portion of human IsK protein (amino acids 67-129) (Accession P15382). View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Western blot: 1:100-1:200 on rat heart membranes, 1:200-1:1,000 on IsK expression Sf9 cells using ECL. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 120 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of PBS. For positive control, in Western blot using 20 ng of protein per minigel lane. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P15382 View All» Entrez Gene Number: NM_000219.2 View All» Gene Symbol:
  • KCNE1

  • minK

  • JLNS2

  • MGC33114

  • ISK

  • MinK

  • LQT5

  • JLNS
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: KCNE1 together with KCNQ1 encode the two subunits of the K+ channel responsible for the delayed-rectifier K+ current in cardiac myocytes (referred to as IsK). View All» UniProt Summary: FUNCTION: SwissProt: P15382 # Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).SIZE: 129 amino acids; 14675 Da SUBUNIT: Associates with KCNQ1/KVLQT1 and KCNH2/HERG.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells.PTM: Phosphorylation inhibits the potassium current (By similarity).DISEASE: "SwissProt: P15382 # Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS) [MIM:220400]. JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram. & Defects in KCNE1 are the cause of long QT syndrome type 5 (LQT5) [MIM:176261]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE1 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents."SIMILARITY: SwissProt: P15382 ## Belongs to the potassium channel KCNE family. View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel IsK Antibody | AB5202-200UL View All» Concentration: 0.6 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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