货号：AB5186-50UL

品牌：Merck Millipore

规格：50UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel Kv2.1 Antibody | AB5186-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a full length Kv2.1 protein. Does not cross react with any other potassium channel antigens tested so far. SPECIES REACTIVITIES: Should work in mouse (100% epitope homology) and in human and rabbit (88% epitope homology). Other species have not been tested. View All» Immunogen: Purified peptide from rat Kv2.1 (amino acids 841-857) (Accession P15387), View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:250-1:500 using ECL on rat brain membranes. Immunohistochemistry using rat brain sections. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder in phosphate buffered saline, pH 7.4, containing 5% sucrose and 0.025% sodium azide). The stock solution of the antigen can be made up using 50 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Purified immunoglobulin by Protein A. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q14721 View All» Entrez Gene Number: NM_004975.2 View All» Gene Symbol:

• KCNB1

• KV2.1

• h-DRK1

• Kv2.1

• DRK1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» Entrez Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. View All» UniProt Summary: FUNCTION: SwissProt: Q14721 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.SIZE: 858 amino acids; 95878 Da SUBUNIT: Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DOMAIN: SwissProt: Q14721 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. & The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.PTM: Phosphorylated on serine residues in the C-terminal cytoplasmic tail (By similarity).SIMILARITY: Belongs to the potassium channel family. B (Shab) subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel Kv2.1 Antibody | AB5186-50UL View All» Concentration: 1 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Purified View All» Host: Rabbit View All»
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