货号：AB5126

品牌：Merck Millipore

规格：50Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Melanocortin Receptor-1 Antibody | AB5126 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Melanocyte Stimulating Hormone Receptor (MSH-R), also called Melanotropin Receptor, or Melanocortin-1 Receptor (MC1-R), is a 315 aa transmembrane protein belonging to the family 1 of G-Protein coupled receptors. It is a receptor for MSH (a, b, g) and ACTH. Its activity is mediated by G-proteins that activate adenylate cyclase. It is found in Melanocytes and corticoadrenal tissue as well as various tissues like adrenal gland, leukocytes, lung, lymph node, ovary, testis, pituitary, placenta, spleen and uterus. Mouse MSH-R. Reactivity with other species has not been confirmed. The immunogen sequence shows 70% homology with human, 66% with bovine, sheep and horse, and 60% with canine. View All» Immunogen: A 21 mer peptide (designated MCR11) from the 3rd cytoplasmic domain of mouse MC1-R. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1-10 μg/mL using Chemiluminescence technique ELISA: 1:10,000 - 100,000 Optimal working dilutions must be determined by end user. View All» Presentation: Affinity Purified immunoglobulin. Liquid in PBS, 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q01726 View All» Entrez Gene Number: NM_002386.2 View All» Gene Symbol:

• MC1R

• MSHR

• MSH-R

• MGC14337

• MC1-R
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. View All» UniProt Summary: FUNCTION: SwissProt: Q01726 # Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.SIZE: 317 amino acids; 34706 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue.SIMILARITY: SwissProt: Q01726 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Melanocortin Receptor-1 Antibody | AB5126 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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