货号：AB5084P

品牌：Merck Millipore

规格：50Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine D2 Receptor Antibody | AB5084P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for Dopamine Receptor D2 short and long form. Dopamine D2 receptor is known to exist in the short (D2S) and the long (D2L) forms that are encoded by splice variants of a single gene and differ only by the presence of an additional 29 amino acid in the intracellular, cytoplasmic loop 3 (1). D2L receptor is a 446 aa, G-protein coupled and transmembrane receptor protein (2). The immunogen peptide shows no significant homology with other dopamine receptors (D1 and D3-D5). View All» Molecular Weight: 50 kDa View All» Immunogen: A 28 amino acid peptide sequence from the human D2 receptor within the cytoplasmicloop #3. View All» Background Information: The Dopamine D2 Receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. 2 isoforms are reported for the D2 Dopamine Receptor, Isoform 1 and isoform 2 which are expressed in the pituitary and brain; Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Monkey
  View All» Species Reactivity Note: Human, mouse, rat and monkey. View All» Application Notes: Western blot: 1-10 µg/mL (Chemiluminescence technique) The predicted size of D2 is approximately 50 kDa. However, additional bands at approximately 68 and 100 kDa, and others are typically seen in various tissues (Boundy et al. 1993; Sakata et al. 1992; Farooqui et al. 199; Farooqui & Prasad 1992, BBRC; Brock et al. 1992; Farooqui & Prasad 1992, Life Sci). Approximately 100-400 µg of membrane protein/lane should be loaded to visualize various bands. Immunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed sections on a previous lot.Immunohistochemistry: 1-20 µg/mL on paraformaldehyde fixed sections. Immunoprecipitation: 1-10 μg/mL using 100-400 μg of protein on a previous lot. An antibody made to this epitope has been shown to immunoprecipitate both the long and short forms (2).ELISA: 0.5-1.0 μg/mL (1 μg/mL immunogen peptide (Catalog number AG221)/well) of a previous lot was used on ELISA.Optimal working dilutions must be determined by the end user. View All» Control: Monkey brain tissue, rat brain lysate View All» Quality Assurance: Routinely evaluated by Western Blot on human brain lysates.Western Blot Analysis: 1:1000 dilution of this lot detected Dopamine Receptor D2 on 10 μg of human brain lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal liquid in PBS with 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P14416 View All» Entrez Gene Number: NM_000795.2 View All» Gene Symbol:
  • DRD2

  • D2DR

  • D2R
    View All» Alternate Names: Dopamine D2 receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunohistochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. View All» UniProt Summary: FUNCTION: SwissProt: P14416 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.SIZE: 443 amino acids; 50619 Da SUBUNIT: Interacts with GPRASP1, neurabin-2 and CLIC6 (By similarity). Interacts with CADPS and CADPS2.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.DISEASE: SwissProt: P14416 # It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia. & Defects in DRD2 are associated with myoclonus dystonia (MD) [MIM:159900]; also known as myoclonic dystonia, alcohol- responsive dystonia and dystonia-11 (DYT11). MD is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.SIMILARITY: SwissProt: P14416 ## Belongs to the G-protein coupled receptor 1 family View All» Brand Family: Chemicon View All» Product Name: Anti-Dopamine D2 Receptor Antibody | AB5084P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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