货号：AB5052

品牌：Merck Millipore

规格：200Ug

目录价：￥6206.00

市场价格：￥5275.10

会员价格：￥4964.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glycine Receptor Antibody | AB5052 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes glycine receptor alpha1. Shows cross reactivity to glycine receptor alpha2. subunits The antibody has been used successfully in Western blot and immunoprecipitation assays with cell extracts containing recombinant human glycine receptors and with homogenates of mouse spinal cord. By Western blot the antibody recognizes a protein with a molecular weight of ~ 48 kD. View All» Immunogen: Peptide from the amino terminus of the human alpha1 glycine receptor subunit conjugated to KLH. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:1000 using ECL Immunoprecipitation: 1:10 following the protocol of Raymond et al., Nature (1993) 361:637-641. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5mM) some residual salt may be present. Reconstitute with 100 μL of PBS. Contains no preservatives. View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P23415 View All» Entrez Gene Number: NM_000171.2 View All» Gene Symbol:
  • GLRA1

  • MGC138878

  • STHE

  • MGC138879
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. The GLRB gene (MIM 138492) encodes the beta subunit of the receptor.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P23415 # The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).SIZE: 457 amino acids; 52624 Da SUBUNIT: Pentamer composed of alpha and beta subunits.SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.DISEASE: SwissProt: P23415 # Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.SIMILARITY: SwissProt: P23415 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.MISCELLANEOUS: The alpha subunit binds strychnine. View All» Brand Family: Chemicon View All» Product Name: Anti-Glycine Receptor Antibody | AB5052 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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