货号：AB5046P

品牌：Merck Millipore

规格：25Ug

目录价：￥1295.00

市场价格：￥1100.75

会员价格：￥1036.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NMDAR1 Splice Variant C1 Antibody | AB5046P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for the NMDAR1 C1 splice variant. AB5046P recognizes the C1 splice insert present in NR1 variants, 1a, 1b, 3a and 3b. {Gorter et al, (1997), "The Role of Alternative Splicing of the NMDAR1 Receptor Subunit in Synaptic Plasticity" Chapter 4, pg 99, in The Ionotropic Glutamate Receptors , Monaghan, D.T. and Weinhold, R.J. (eds), Humana Press, New Jersey) By Western blot the antibody recognizes a protein with molecular weight of 100 kDa. View All» Immunogen: Peptide corresponding to the C-terminus of the rat NMDAR1 C1 splice variant. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:1,000 using ECL on rat brain lysate. Immunohistochemistry: 1:1,000. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q05586 View All» Entrez Gene Number:

• NM_000832.5

• NM_007327.2

• NM_021569.2
  View All» Gene Symbol:
  • GRIN1

  • Glutamate

  • NMDAR1

  • NMDA1

  • NR1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. View All» UniProt Summary: FUNCTION: SwissProt: Q05586 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).SIZE: 938 amino acids; 105373 Da SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).SIMILARITY: SwissProt: Q05586 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family. View All» Brand Family: Chemicon View All» Product Name: Anti-NMDAR1 Splice Variant C1 Antibody | AB5046P View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 25 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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